Breast Cancer Anti-Estrogen Resistance-1 Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Signaling Protein -> Adaptor Signaling Protein -> Breast Cancer Anti-Estrogen Resistance-1 Protein

Breast Cancer Anti-Estrogen Resistance-1 Protein Definition

Encoded by human BCAR1 Gene, conserved ubiquitous 870-amino acid 116 kD cytoplasmic p130CAS (CAS Family) is an adaptor molecule: Ser-region, NH-SH3, central YXXP motif SH2-binding site substrate domain, SRC SH3-binding site COOH Pro-rich binding region, and C-terminal HLH. SH3 localizes CAS to focal adhesions; interacts with FAK1 P-rich region. FAK1 phosphorylates CAS YDYVHL motif. SRCs phosphorylate CAS. CAS SH2-binding sites may bind CRK, NCK, and ABL. CAS HLH may dimerize CASL. CAS Ser region promotes serum response. CAS moves to focal adhesions upon integrin triggered Y-phosphorylation. CAS complexes with CRKL and LYN. CAS functions in cardiovascular development, actin assembly, cell migration, and growth. Over expression confers breast cancer anti-estrogen resistance. (from SWISS-PROT, OMIM, and NCI)

Breast Cancer Anti-Estrogen Resistance-1 Protein Synonyms

Breast Cancer Anti-Estrogen Resistance 1 Protein, BCAR1, BCAR1 Protein, CAS, CRK-Associated Substrate, CRKAS, p130CAS

Terms in Breast Cancer Anti-Estrogen Resistance-1 Protein category

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