Bretylium Tosylate
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Bretylium Tosylate Definition
The tosylate salt form of bretylium, a quaternary ammonium salt and non-selective adrenergic neuronal blocking agent with anti-arrhythmic properties. Bretylium tosylate is selectively taken up into peripheral nerve terminals and initially causes a release of norepinephrine from sympathetic nerve endings, thereby causing a sympathomimetic effect. This is followed by a prolonged anti-adrenergic action which prevents further discharge of neurotransmitter from sympathetic nerve endings. Its myocardial effects include a prolongation of action potential as well as refractory period. This drug is used to treat and suppress ventricular arrhythmias, particularly ventricular fibrillation and ventricular tachycardia.
Bretylium Tosylate Synonyms
Bretylium Tosylate, (o-Bromobenzyl)ethyldimethylammonium p-Toluenesulfonate, 2-Bromo-N-ethyl-N,N-dimethylbenzenemethanaminium 4-Methylbenzenesulfonate, BRETYLIUM TOSYLATE, Bretylol, Darentin
Terms in Bretylium Tosylate category
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