C-X-C Motif Chemokine Receptor-3

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Cytokine Receptor -> Chemokine Receptor -> C-X-C Motif Chemokine Receptor-3

C-X-C Motif Chemokine Receptor-3 Definition

CD183 is a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to CD183. A hallmark of CD183 is its prominent expression in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that CD183 and its chemokines participate in the recruitment of inflammatory cells. (from LocusLink)

C-X-C Motif Chemokine Receptor-3 Synonyms

Chemokine (C-X-C Motif) Receptor 3, CXCR3, G Protein-Coupled Receptor 9, IP10 Receptor, Mig Receptor

C-X-C Motif Chemokine Receptor-3

C-X-C Motif Chemokine Receptor-3 Definition

C-X-C Motif Chemokine Receptor-3 Synonyms

Terms in C-X-C Motif Chemokine Receptor-3 category