CAAX-Farnesyltransferase Alpha-Subunit
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Protein Complex Subunit -> CAAX-Farnesyltransferase Alpha-Subunit
CAAX-Farnesyltransferase Alpha-Subunit Definition
Encoded by human FNTA Gene (Protein Prenyltransferase Alpha Subunit Family), 379-aa 44-kDa CAAX Box Farnesyltransferase Alpha Subunit is part of 100-kD heterodimeric Farnesyl Protein Transferase or GGTase-I (different beta chain), which catalyze 15-C farnesyl or 20-C geranylgeranyl thioether linkage to the C-terminal Cys in C(ys)AAX boxes of many proteins as a means of membrane localization. FTase and GGTase beta chains are catalytic for specific substrates. With both conserved alpha and beta subunits essential for catalytic activity, FNTA (5 PFTA repeats) may promote a stable complex with substrate; beta binds the substrate. Interacting with TGF-beta and Activin Type I receptors, FNTA is likely a key component of p21ras signaling, a farnesyltransferase substrate; membrane localization and activity of RAS is dependent on farnesylation. (NCI)
CAAX-Farnesyltransferase Alpha-Subunit Synonyms
CAAX Box Farnesyltransferase Alpha Subunit, CAAX Box Farnesyltransferase Alpha, FNTA, FPTA, FTase-Alpha, GGTase-I-Alpha, PGGT1A, Protein Farnesyltransferase Type I Alpha Subunit, Protein Farnesyltransferase/Geranylgeranyltransferase Type I Alpha Subunit, RAS Proteins Prenyltransferase Alpha, Type I Protein Geranyl-Geranyltransferase Alpha Subunit
Terms in CAAX-Farnesyltransferase Alpha-Subunit category
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