Cancer Terms

CB10-277

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Alkylating Agent -> Antineoplastic Alkylating Agent -> Triazene Compound -> CB10-277

CB10-277 Definition

A synthetic derivative of dimethylphenyl-triazene related to dacarbazine, with antineoplastic properties. Related to the agent dacarbazine, CB10-277 is converted in vivo to a monomethyl triazene form that alkylates DNA, resulting in inhibition of DNA replication and repair; in addition, this agent may act as a purine analogue, resulting in inhibition of DNA synthesis, and may interact with protein sulfhydryl groups. (NCI04)

CB10-277 Synonyms

CB10-277, 1-p-carboxy-3,3-dimethylphenyltriazine

Terms in CB10-277 category



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