CBL Protein
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CBL Protein Definition
The cellular homologue of v-cbl, CBL protein is expressed in a range of hemopoietic lineages. Malignancies are associated with translocations of the CBL gene. Adaptor protein CBL2, containing a RING finger and multiple SH3 domains, encodes a protein similar to SLI1, a negative regulator of an EGF receptor tyrosine kinase homologue. Through its SH2 domain, CBL regulates activated tyrosine-phosphorylated receptor PTK ubiquitination as an E3 ubiquitin ligase and recruits, and activates, an E2 ubiquitin-conjugating enzyme through its RING domain. CBL is recruited to the tyrosine kinase insulin receptor by CAP adaptor protein, through a CAP SH3 domain. Upon CBL phosphorylation, CAP/CBL dissociates from the receptor to complex with caveolar flotillin and localize to plasma membrane lipid rafts. (from OMIM 165360 and NCI)
CBL Protein Synonyms
CBL Protein, CBL, CBL Gene Product, CBL2 Gene Product
Terms in CBL Protein category
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