CD4 Antigen
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CD4 Antigen Definition
CD4 Antigen, encoded by the CD4 gene, is a T-cell surface glycoprotein. CD4 has a role in cell-cell interactions and may act in signal transduction. CD4 is a accessory protein for MHC class-II antigen/T-cell receptor interaction and functions to initiate or augment the early phase of T-cell activation. CD4 enhances T-cell sensitivity to antigen and binds to LCK, which phosphorylates CD3-zeta. CD4 Antigen also serves as an HIV receptor, binding directly to the envelope protein gp120 on HIV. (From LocusLink, OMIM and NCI)
CD4 Antigen Synonyms
CD4 Antigen, CD4, CD4 Antigen (P55), CD4 Protein, OKT4 Antigen, T-Cell Antigen T4/Leu3, T-Cell Surface Antigen T4/Leu-3
Terms in CD4 Antigen category
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