CDKN1C wt Allele

Cancer Terms -> Gene -> Cell Cycle Gene -> Cyclin-Dependent Kinase Inhibitor Gene -> CDKN1C Gene -> CDKN1C wt Allele

CDKN1C wt Allele Definition

Human CDKN1C wild-type allele located in the vicinity of 11p15.5 and is approximately 2 kb in length. This allele, which encodes cyclin-dependent kinase inhibitor 1C protein, plays a negative role in the regulation of cellular proliferation by inhibiting several G1 cyclin/Cdk complexes. Mutations of the gene, which generates variant alleles have been implicated in both sporadic cancers and Beckwith-Wiedemann syndrome, suggesting that it is a tumor suppressor candidate.

CDKN1C wt Allele Synonyms

CDKN1C wt Allele, BWCR, BWS, Cyclin-Dependent Kinase Inhibitor 1C wt Allele, KIP2, KIP2 Gene, P57-Kip2 Gene, WBS, p57

Terms in CDKN1C wt Allele category

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