CHK2 Inhibitor LY2603618
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Enzyme Inhibitor ->
Protein Kinase Inhibitor ->
Serine Threonine Kinase Inhibitor -> CHK2 Inhibitor LY2603618
CHK2 Inhibitor LY2603618 Definition
An inhibitor of the cell cycle checkpoint kinase 2 (chk2) with potential chemopotentiating activity. Chk2 inhibitor LY2603618 binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk2, an ATP-dependent serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint system and is activated by double-stranded breaks (DSBs); activated chk2 is overexpressed by a variety of cancer cell types.
CHK2 Inhibitor LY2603618 Synonyms
CHK2 Inhibitor LY2603618, Checkpoint Kinase 2 Inhibitor LY2603618, LY2603618
Terms in CHK2 Inhibitor LY2603618 category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.