CI-1040
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Mitogen-Activated Protein Kinase Kinase Inhibitor -> CI-1040
CI-1040 Definition
An agent that inhibits both mitogen-activated protein kinase kinases 1 and 2 (MEK1 and MEK2), substrates of Raf and phosphorylates extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), preventing phosphorylation and activation of the Mitogen-Activated Protein Kinase (MAPK) pathways, involved with signal transduction pathways and tumor proliferation.
CI-1040 Synonyms
CI-1040, PD 184352/CI-1040, PD-184352
Terms in CI-1040 category
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