CNGRC Peptide-Tumor Necrosis Factor Alpha Conjugate
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CNGRC Peptide-Tumor Necrosis Factor Alpha Conjugate Definition
A cytokine-peptide conjugate composed of the cytokine tumor necrosis factor alpha (TNF-alpha) chemically linked to the peptide CNGRC. The peptide moiety CNGRC, a ligand for the membrane-bound metalloprotease CD13, binds to endothelial cells of the angiogenic vasculature that express CD13 (also known as aminopeptidase N); subsequently, the TNF-alpha moiety induces apoptosis in endothelial cells expressing CD13, thereby inhibiting tumor-associated angiogenesis. (NCI05)
CNGRC Peptide-Tumor Necrosis Factor Alpha Conjugate Synonyms
CNGRC Peptide-TNF Alpha Conjugate, NGR-hTNF
Terms in CNGRC Peptide-Tumor Necrosis Factor Alpha Conjugate category
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