CREB Family Gene

Cancer Terms -> Gene -> Transcription Factor Gene -> CREB Family Gene

CREB Family Gene Definition

Ubiquitously or widely expressed human CREB Family Genes (bZIP/CREB Family) encode conserved cAMP Responsive Element Binding Proteins, nuclear bZIP domain dimeric transcription factors that bind to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters and induce gene transcription in response to cAMP signaling pathways. CREB proteins bind to DNA as a homodimer or a heterodimer with JUN/c-Jun or ATF2/CREBP1. Increased cAMP levels following stimulation activate cAMP-dependent protein kinase A, which phosphorylates CREB proteins that stimulate transcription of cAMP-responsive genes. Calcium-regulated CREB transcription factors integrate calcium and cAMP signals. cAMP pathways provide a chief means by which cellular growth, differentiation, and function can be influenced by extracellular signals. (NCI)

CREB Family Gene Synonyms

CREB Family Gene

Terms in CREB Family Gene category

ATF2 Gene
CREB1 Gene
CREB3 Gene
CREB4 Gene
CREB5 Gene
CREBL2 Gene