CTLA4-Ig

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Biological Response Modifier -> Immunosuppressant -> CTLA4-Ig

CTLA4-Ig Definition

A human fusion protein with immunosuppressive activity. It consists of the binding domain of human cytotoxic T-lymphocyte-associated antigen 4 and human IgG1. CTLA4-Ig works by binding to CD80 and CD86 on antigen presenting cells, thereby blocking the engagement of CD28 on T-cells, a co-stimulatory signal required for full T-cell activation. This co-stimulatory blocker prevents T-cell activation, and proliferation, and subsequent cytokine production. This T-cell regulatory protein may be useful in treating autoimmune diseases such as rheumatoid arthritis, and may help prevent organ transplant rejection.

CTLA4-Ig Synonyms

Abatacept, ABATACEPT, BMS-188667, CTL A4-Ig B7 Inhibitor, CTLA4-Ig, Orencia, RG2077, cytotoxic T lymphocyte-associated antigen-4

Terms in CTLA4-Ig category

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