CXCR4 Inhibitor MSX-122
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CXCR4 Inhibitor MSX-122 Definition
An orally bioavailable inhibitor of CXCR4 with potential antineoplastic and antiviral activities. CXCR4 inhibitor MSX-122 binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor-1 (SDF-1) to the CXCR4 receptor and receptor activation, which may result in decreased tumor cell proliferation and migration. CXCR4, a chemokine receptor belonging to the GPCR (G protein-coupled receptor) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types; it is also a co-receptor for HIV entry into T cells.
CXCR4 Inhibitor MSX-122 Synonyms
CXCR4 Inhibitor MSX-122, MSX-122
Terms in CXCR4 Inhibitor MSX-122 category
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