Cadherin

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Cell Adhesion Molecule -> Cadherin

Cadherin Definition

The cadherins are transmembrane glycoproteins involved in calcium dependent specific cell-cell adhesion through homophilic binding. They are crucial for morphogenesis and synapse formation, but also are involved in tumor invasion. The classical cadherins have five homologous extracellular domains and a cytosolic domain which binds through catenin to the cytoskeleton. The extracellular domains are immunoglobulin-like beta-sandwiches comprising usually 7 strands in the two sheets.

Cadherin Synonyms

Cadherin

Terms in Cadherin category

E-Cadherin
H-Cadherin
N-Cadherin
P-Cadherin
VE-Cadherin