Cadherin Domain
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Cadherin Domain Definition
Evolutionary related to desmosomal desmogleins, cadherins contain a signal sequence, a propeptide of around 130 residues, an extracellular domain of around 600 residues, a single transmembrane domain, and a well-conserved C-terminal cytoplasmic domain of about 150 residues. The extracellular domain typically consists of four Cadherin Domain repeats of about 110 residues; an adjacent fifth domain contains four conserved cysteines. The domain includes conserved Asp and Arg residues that may be involved in calcium binding. Tissue-specific cadherin glycoproteins are responsible for homophilic calcium-dependent cell-cell adhesion likely involved in cell type sorting during morphogenesis, histogenesis, and regeneration. They may also regulate tight and gap junctions. (NCI)
Cadherin Domain Synonyms
Cadherin Domain
Terms in Cadherin Domain category
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