Calcineurin-A Alpha

Cancer Terms -> Gene Product -> Protein -> Protein Complex Subunit -> Calcineurin-A Alpha

Calcineurin-A Alpha Definition

Encoded by human PPP3CA Gene (PPP Phosphatase/PP-2B Family), 521-aa 59-kDa Calcineurin A Alpha is a calmodulin-binding catalytic subunit of ubiquitous heterodimeric Ca(2+)/calmodulin-regulated protein phosphatase Calcineurin involved in many biologic activities as a modifier of phosphorylation status. Calcineurin catalytic subunits are derived from alternatively spliced highly conserved PPP3CA, PPP3CB, PPP3CC genes. IGF1 stimulates a myocyte switch to glycolytic metabolism by activating calcineurin A, inducing nuclear translocation of NFATC1 transcription factor, and association of calcineurin, GATA2, and dephosphorylated NFATC1. DSCR1 interacts with calcineurin A in the linker region between the catalytic domain and the calcineurin B-binding domain. DSCR1 and ZAKI4 may inhibit calcineurin-dependent gene transcription through inhibition of NFAT translocation to the nucleus. (NCI)

Calcineurin-A Alpha Synonyms

Calcineurin A Alpha, CAM-PRP Catalytic Subunit, Calmodulin-Dependent Calcineurin A Subunit Alpha Isoform, PPP3CA, Protein Phosphatase 3 Catalytic Subunit Alpha Isoform, Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform

Calcineurin-A Alpha

Calcineurin-A Alpha Definition

Calcineurin-A Alpha Synonyms

Terms in Calcineurin-A Alpha category