Calcium-Binding Domain

Cancer Terms -> Anatomic Structure System or Substance -> Microanatomy -> Macromolecular Structure -> Protein Structure -> Protein Domain -> Ligand Binding Domain -> Metal Binding Site -> Calcium-Binding Domain

Calcium-Binding Domain Definition

Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1, 3, 5, 7, 9 and 12; these residues are denoted by X, Y, Z, -Y, -X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand). (From InterPro IPR002048)

Calcium-Binding Domain Synonyms

Calcium-Binding Domain, Calcium-Binding Motif

Terms in Calcium-Binding Domain category

EF-Hand Domain