Cancer Terms

Camptothecin Analogue TLC388

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Enzyme Inhibitor -> Topoisomerase Inhibitor -> Topoisomerase-I Inhibitor -> Camptothecin Analogue -> Camptothecin Analogue TLC388

Camptothecin Analogue TLC388 Definition

A synthetic analogue of camptothecin with potential antineoplastic and radio-sensitizing activities. Camptothecin analogue TLC388 selectively stabilizes topoisomerase I-DNA covalent complexes during S-phase, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. Topoisomerase I relaxes negative super-coiled DNA during replication and transcription. This agent has been chemically modified to enhance the potency and stability of camptothecin.

Camptothecin Analogue TLC388 Synonyms

Camptothecin Analogue TLC388, Lipotecan, TLC388

Terms in Camptothecin Analogue TLC388 category



Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods

No reproduction or republication permitted.