Camptothecin Analogue TLC388
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Camptothecin Analogue TLC388 Definition
A synthetic analogue of camptothecin with potential antineoplastic and radio-sensitizing activities. Camptothecin analogue TLC388 selectively stabilizes topoisomerase I-DNA covalent complexes during S-phase, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. Topoisomerase I relaxes negative super-coiled DNA during replication and transcription. This agent has been chemically modified to enhance the potency and stability of camptothecin.
Camptothecin Analogue TLC388 Synonyms
Camptothecin Analogue TLC388, Lipotecan, TLC388
Terms in Camptothecin Analogue TLC388 category
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