Camptothecin Sodium
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Camptothecin Sodium Definition
The sodium salt of camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. The sodium salt of camptothecin is more water-soluble than the parent molecule. (NCI04)
Camptothecin Sodium Synonyms
Camptothecin Sodium, Camptothecin Sodium Salt, Camptothecin sodium, Camptothecin, sodium salt, Sodium camptothecin
Terms in Camptothecin Sodium category
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