Cancer Terms

Candesartan Cilexetil

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Agent Affecting Cardiovascular System -> Antihypertensive Agent -> Angiotensin II Receptor Antagonist -> Candesartan Cilexetil

Candesartan Cilexetil Definition

A synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with antihypertensive activity. After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 (AT1) in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of AT1 in the adrenal gland inhibits angiotensin II-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure.

Candesartan Cilexetil Synonyms

Candesartan Cilexetil, Atacand, Blopress, CANDESARTAN CILEXETIL

Terms in Candesartan Cilexetil category



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