Cancer Terms

Capecitabine

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Antimetabolite -> Pyrimidine Antagonist -> Capecitabine

Capecitabine Definition

A fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand. (NCI04)

Capecitabine Synonyms

Capecitabine, 5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine, CAPECITABINE, Ro 09-1978/000, Xeloda, capecitabine

Terms in Capecitabine category



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