Caspase-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Hydrolase -> Protease -> Cysteine Proteinase -> Caspase -> Caspase-1

Caspase-1 Definition

Caspase-1, encoded by the CASP1 gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of the similar gene in mouse suggested its role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. (From LocusLink)

Caspase-1 Synonyms

Caspase-1, CASP-1, CASP1, Caspase 1, Apoptosis-Related Cysteine Protease, Caspase 1, Apoptosis-Related Cysteine Protease (Interleukin 1, Beta, Convertase), EC 3.4.22.36, ICE, IL-1 Beta Converting Enzyme, IL-1BC, IL-1b Converting Enzyme, IL1B-Convertase, IL1BC, IL1BCE, Interleukin 1-B Converting Enzyme, Interleukin 1-Beta Convertase, Interleukin-1 Beta Converting Enzyme, P45

Caspase-1

Caspase-1 Definition

Caspase-1 Synonyms

Terms in Caspase-1 category