Caspase-10

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Hydrolase -> Protease -> Cysteine Proteinase -> Caspase -> Caspase-10

Caspase-10 Definition

Caspase-10 originally was identified as a novel ICE/CED-3 protease, designated FLICE2 (FADD (fas-associated via death domain)-like ICE 2). It has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits TNFR1 to form complexes with these receptors. Caspase-10 is therefore involved in the TNFR1 induced apoptosis. Caspase-10 cleaves and activates caspase-3, -4, -6, -7, -8, and -9, which causes the proteolytic cleavage of many key proteins such as PARP (poly (ADP-ribose) polymerase). Cleavage of PARP occurs in many different systems during apoptosis and is the hallmark of programmed cell death.

Caspase-10 Synonyms

Caspase-10, ALPS2, Apoptotic Protease MCH-4, CASP10, CASP10 Protein, Caspase 10, Apoptosis-Related, Caspase 10, Apoptosis-Related Cysteine Protease, Cysteine Protease, EC 3.4.22.-, FADD-Like ICE2, FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2, FLICE2, Fas-Associated Death Domain Protein, ICE-Like Apoptotic Protease 4, Interleukin-1B-Converting Enzyme 2, MCH4

Caspase-10

Caspase-10 Definition

Caspase-10 Synonyms

Terms in Caspase-10 category