Caspase-2

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Hydrolase -> Protease -> Cysteine Proteinase -> Caspase -> Caspase-2

Caspase-2 Definition

Caspase-2, encoded by the CASP2 gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspase-2 is synthesized as an inactive proenzyme which is activated by an alternative CD 95 pathway which involves the formation of a complex between oligomerized CD 95 and the accessory proteins RIP and RAIDD. After activation, caspase 2 induces apoptosis by triggering the caspase cascade. The proteolytic cleavage of this caspase is induced by a variety of apoptotic stimuli. In contrast to caspase 8, caspase 2 contains no death effector domain. (From LocusLink and NCI)

Caspase-2 Synonyms

Caspase-2, CASP-2, CASP2, Caspase 2, Apoptosis-Related Cysteine Protease, Caspase 2, Apoptosis-Related Cysteine Protease (Neural Precursor Cell Expressed, Developmentally Down-Regulated 2), EC 3.4.22.-, ICH-1, ICH-1 Protease, ICH-1L, ICH-1L/1S, ICH1, NEDD2, NEDD2 Apoptosis Regulatory Protein, Neural Precursor Cell Expressed, Developmentally Downregulated 2

Caspase-2

Caspase-2 Definition

Caspase-2 Synonyms

Terms in Caspase-2 category