Caspase-4

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Hydrolase -> Protease -> Cysteine Proteinase -> Caspase -> Caspase-4

Caspase-4 Definition

Caspase-4, encoded by the CASP4 Gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. Caspase-4 is able to cleave and activate its own, as well as caspase 1, precursor proteins. When overexpressed, this gene has been shown to induce cell apoptosis. Alternative splicing results in 3 transcript variants encoding distinct isoforms. (From LocusLink and NCI)

Caspase-4 Synonyms

Caspase-4, Apoptotic Cysteine Protease Mih1/TX, CASP-4, CASP4, CASP4 Protein, Caspase 4, Apoptosis-Related Cysteine Protease, EC 3.4.22.-, ICE(rel)II, ICErel-II, ICH-2, Mih1/TX, TX, TX Protease

Caspase-4

Caspase-4 Definition

Caspase-4 Synonyms

Terms in Caspase-4 category