Caspase-6
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Caspase-6 Definition
Caspase-6, encoded by the CASP6 Gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Caspase-6 can be processed by caspases 7, 8 and 10, and functions as a downstream enzyme in the activation cascade of caspases responsible for apoptosis execution. It cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Alternative splicing of this gene results in two transcript variants which encode different isoforms. Its overexpression promotes programmed cell death. (From LocusLink, Swiss-Prot and NCI)
Caspase-6 Synonyms
Caspase-6, Apoptotic Cysteine Protease MCH2, Apoptotic Protease Mch-2, CASP6, CASP6 Protein, CASPASE 6, Apoptosis-Related Cysteine Protease, EC 3.4.22.-, MCH2
Terms in Caspase-6 category
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