Caspase-9

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Hydrolase -> Protease -> Cysteine Proteinase -> Caspase -> Caspase-9

Caspase-9 Definition

Caspase-9 is encoded by the CASP9 Gene. Caspase-9 is the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and dATP. Caspase-9 and APAF1 bind to each other in the presence of cytochrome c and dATP, an event that leads to caspase-9 activation. Activation of procaspase-9 by APAF1 requires proteolytic cleavage to generate the mature caspase molecule. Activated caspase-9 in turn cleaves and activates caspase-3. APAF1-mediated processing of procaspase-9 occurs at asp315 by an intrinsic autocatalytic activity of procaspase-9 itself. APAF1 can form oligomers and may facilitate procaspase-9 autoactivation by oligomerizing its precursor molecules. Once activated, caspase-9 can initiate a biochemical cascade involving the downstream executioners caspase-3, -6, and -7. Alternative splicing of this gene results in two transcript variants which encode different isoforms. (From LocusLink, OMIM and NCI)

Caspase-9 Synonyms

Caspase-9, APAF-3, APAF3, Apoptotic Protease Activating Factor 3, Apoptotic Protease MCH-6, CASP-9, CASP9, CASP9 Protein, Caspase 9, Apoptosis-Related Cysteine Protease, EC 3.4.22.-, ICE-LAP6, ICE-Like Apoptotic Protease 6, MCH6

Caspase-9

Caspase-9 Definition

Caspase-9 Synonyms

Terms in Caspase-9 category