Cathepsin-L

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Hydrolase -> Protease -> Cathepsin -> Cathepsin-L

Cathepsin-L Definition

Cathepsin L, encoded by the CTSL Gene, is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. It is important for the overall degradation of proteins in lysosomes. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. Cathepsin L has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. Cathepsin L is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene. (From LocusLink and NCI)

Cathepsin-L Synonyms

Cathepsin L, CATL, CTSL, CTSL Protein, EC 3.4.22.15, MEP, Major Excreted Protein

Cathepsin-L

Cathepsin-L Definition

Cathepsin-L Synonyms

Terms in Cathepsin-L category