Caudal Type Homeobox Transcription Factor-2

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Factor -> Homeobox Protein -> Caudal Type Homeobox Transcription Factor-2

Caudal Type Homeobox Transcription Factor-2 Definition

Caudal Type Homeo Box Transcription Factor 2, encoded by the human CDX2 gene, is a homeodomain protein. This nuclear protein is involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. It is important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Phosphorylation of Ser-60 of this protein mediates the transactivation capacity. CDX3 binds an A/T-rich sequence in the insulin promoter and stimulate its transcription. Increased CDX2 mRNA is associated with chronic atrophic gastritis and expression of CDX2 may trigger the initiation and development of intestinal metaplasia. In contrast, markedly reduced or absent CDX2 expression is noted in most large cell minimally differentiated carcinomas. (From LocusLink, Swiss-Prot, OMIM and NCI)

Caudal Type Homeobox Transcription Factor-2 Synonyms

Homeobox Protein CDX2, CDX-3, CDX2, CDX2 Protein, CDX3, Caudal Type Homeobox Transcription Factor 2, Caudal-Type Homeo Box Transcription Factor 2, Caudal-Type Homeo Box Transcription Factor 3, Caudal-Type Homeobox Protein 2, Homeobox Protein CDX-2, Insulin-Regulating Transcription Factor CDX3

Terms in Caudal Type Homeobox Transcription Factor-2 category

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