Cell Division Cycle-2-Like-1 Protein
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Cell Division Cycle-2-Like-1 Protein Definition
Cell Division Cycle 2-Like 1, encoded by the CDC2L1 gene, is a member of the p34Cdc2 serine/threonine protein kinase family. CDC2L1 is expressed ubiquitously and acts as a negative regulator of the normal cell cycle progression. It may function in regulating proliferation by phosphorylation and subsequent plasma membrane targeting of galactosyltransferase. This gene is deleted or altered frequently in neuroblastoma with amplified MYCN genes. CDC2L1 can be cleaved by caspases and play roles in cell apoptosis. A large number of the alternatively spliced variants of this gene exist. (From LocusLink, Swiss-Prot and NCI)
Cell Division Cycle-2-Like-1 Protein Synonyms
Cell Division Cycle 2-Like 1, CDC-Related Protein Kinase p58, CDC2L1, Dual Specificity Phosphatase Cdc25A, EC 3.1.3.48, Galactosyltransferase Associated Protein Kinase, M-Phase Inducer Phosphatase 1, PITSLRE B, PITSLRE Protein Kinase Alpha, p58/GTA Protein Kinase
Terms in Cell Division Cycle-2-Like-1 Protein category
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