Cancer Terms

Chloroquine Phosphate

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Anti-Infective Agent -> Antiparasitic Agent -> Antiprotozoal Agent -> Antimalarial Agent -> Chloroquine Phosphate

Chloroquine Phosphate Definition

The phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids.

Chloroquine Phosphate Synonyms

Chloroquine Phosphate, 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, Phosphate (1:2), 7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline Phosphate (1:2), Aralen Phosphate, Avloclor, CHLOROQUINE PHOSPHATE, Tanakan

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