Colchicine-Site Binding Agent

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Antimitotic Agent -> Tubulin Binding Agent -> Colchicine-Site Binding Agent

Colchicine-Site Binding Agent Definition

A class of anti-mitotic compounds that bind to two distinct sites within the beta tubulin subunit; one site, located within the middle domain and close to the alpha/beta dimer interface, corresponds to an approximate residue sequence of 214-241; whereas, the second site is located at the N-terminal domain and corresponds to a residue sequence approximating 1-41. Agents binding at the colchicine site produce a conformational change in the protofilament structure which subsequently impairs the polymerization of tubulin dimers and thereby prevents the formation of microtubules. The subsequent decrease in the amount of formed microtubules causes disassembly of the mitotic spindle resulting from instability of the structure during the mitotic interphase, leading to cell cycle arrest and/or apoptosis.

Colchicine-Site Binding Agent Synonyms

Colchicine-Site Binding Agent, Colchicine-Site Binding Agents

Colchicine-Site Binding Agent

Colchicine-Site Binding Agent Definition

Colchicine-Site Binding Agent Synonyms

Terms in Colchicine-Site Binding Agent category