Collagen IV Alpha-3

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Structural Protein -> Extracellular Matrix Protein -> Collagen -> Collagen IV Alpha-3

Collagen IV Alpha-3 Definition

Collagen IV (Alpha 3),encoded by the human COL4A3 gene, is a subunit of type IV collagen, the major structural component of basement membranes. In Goodpasture syndrome, autoantibodies bind to collagen in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized to the non-collagenous C-terminal domain of this protein. There are 6 alternate transcripts unique to this gene and alternate splicing is restricted to the 6 exons encoding this domain. This protein is widely expressed. Two protein isoforms (1 and 2/Delta26/GPBPD26) are produced by alternative splicing. This gene is also linked to the autosomal recessive Alport syndrome. The mutations contributing to this syndrome are also located within the exons encoding this C-terminal region. This protein phosphorylates the Goodpasture autoantigen in vitro on Ser and Thr residues. Isoform 2 seems less active. (From LocusLink, Swiss-Prot and NCI)

Collagen IV Alpha-3 Synonyms

Collagen IV (Alpha 3), Alpha 3 Type IV Collagen Precursor, COL4A3, COL4A3 Protein, COL4A3BP Protein, Collagen IV, Alpha-3 Polypeptide, Collagen Type IV Alpha 3 Binding Protein, Collagen of Basement Membrane, Alpha-3 Chain, Collagen, Type IV, Alpha 3 (Goodpasture Antigen), EC 2.7.1.37, GPBP Protein, Goodpasture Antigen, STAR-Related Lipid Transfer Protein 11, STARD11 Protein, START Domain-Containing Protein 11, TUMSTATIN, Tumstatin (Human Placenta Collagen Type IV alpha3 Chain NC1 Domain)

Collagen IV Alpha-3

Collagen IV Alpha-3 Definition

Collagen IV Alpha-3 Synonyms

Terms in Collagen IV Alpha-3 category