Colony Stimulating Factor-1
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Colony Stimulating Factor-1 Definition
Synthesized by mesenchymal cells, Macrophage Colony-Stimulating Factor is a 70 kD disulfide-bonded homodimeric glycoprotein cytokine that binds to FMS (a specific high affinity receptor) and stimulates survival, proliferation, and differentiation of committed hematopoietic cells of the related granulocyte and monocyte-macrophage lineages. Three isoforms of M-CSF result from alternative splicing. The active forms may be produced by proteolytic cleavage; precursors may exist as integral membrane proteins. Isoform 1 may undergo rapid proteolytic cleavage to yield an extracellular growth factor. Isoform 3 may exist as an integral membrane protein that undergoes slow proteolysis at the cell surface to yield a soluble growth factor. (from OMIM 120420, SWISS-PROT P09603, and NCI)
Colony Stimulating Factor-1 Synonyms
Colony Stimulating Factor 1, CSF1, Macrophage Colony Stimulating Factor
Terms in Colony Stimulating Factor-1 category
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