Colony Stimulating Factor-2-Receptor Alpha Chain

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Cytokine Receptor -> Colony Stimulating Factor Receptor -> Colony Stimulating Factor-2-Receptor Alpha Chain

Colony Stimulating Factor-2-Receptor Alpha Chain Definition

Expressed as alternative membrane-bound and soluble isoforms (3, 4, and 6) by human CSF2RA Gene (Type I Cytokine Receptor 5 Family), Colony Stimulating Factor 2 Receptor Alpha Chain is a type I membrane protein with a box 1 motif for JAK interaction/activation; a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding; and the alpha subunit of a heterodimeric low affinity receptor for granulocyte-macrophage colony-stimulating factor. The receptor signal transducing beta chain is common to the IL3-, IL5- and GM-CSF receptors. CSF2R transduces the CSF2 signal for proliferation, differentiation, and activation of (primarily) granulocyte and macrophage hematopoietic cells. (NCI)

Colony Stimulating Factor-2-Receptor Alpha Chain Synonyms

Colony Stimulating Factor 2 Receptor Alpha Chain, CD116, CD116 Antigen, CDw116, CSF2R, CSF2RA, GM-CSF Receptor Alpha Subunit, GM-CSF-R-Alpha, GMCSFR, GMR, Granulocyte-Macrophage Colony-Stimulating Factor Receptor Alpha Chain, Low Affinity Granulocyte-Macrophage Colony Stimulating Factor 2 Receptor Alpha

Terms in Colony Stimulating Factor-2-Receptor Alpha Chain category

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