Combretastatin A4 Analogue AVE8062
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Antineoplastic Agent ->
Antimitotic Agent ->
Tubulin Binding Agent ->
Colchicine-Site Binding Agent -> Combretastatin A4 Analogue AVE8062
Combretastatin A4 Analogue AVE8062 Definition
A synthetic water-soluble analogue of combretastatin A4, derived from the South African willow bush (Combretum caffrum), with potential vascular-disrupting and antineoplastic activities. Combretastatin A4 analogue AVE8062 binds to the colchicine binding site of endothelial cell tubulin, inhibiting tubulin polymerization and inducing mitotic arrest and apoptosis in endothelial cells. As apoptotic endothelial cells detach from their substrata, tumor blood vessels collapse; the acute disruption of tumor blood flow may result in tumor necrosis.
Combretastatin A4 Analogue AVE8062 Synonyms
Combretastatin A4 Analogue AVE8062, AC7700, AVE8062
Terms in Combretastatin A4 Analogue AVE8062 category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.