Complement Degradation

Cancer Terms -> Biological Process -> Subcellular Process -> Biochemical Process -> Metabolic Process -> Intermediary Metabolism -> Amino Acid-Peptide-Protein Metabolism -> Protein Degradation Induction -> Complement Degradation

Complement Degradation Definition

Complement Degradation consists of conjugation, transport, oxidation, and/or proteolysis of complement system proteins; sequentially interacting serum proteins (some serine proteases), their receptors, and related regulatory proteins. Activated by cell-surface bound antibody, immune complexes, or a microbial membrane carbohydrate, complex complement cascades (classical or properdin pathway) generate Membrane Attack Complex, which creates target cell wall pores and lysis. The complement system also plays a role in antibody-dependent cytolysis, anaphylaxis, phagocytosis, opsonization, chemotaxis, and hemolysis.