Complement Suppression

Cancer Terms -> Biological Process -> Subcellular Process -> Biochemical Process -> Immunologic Factor Suppression -> Complement Suppression

Complement Suppression Definition

By increased degradation, or by decreased production or activation, Complement Suppression consists of interference with, or restraint of, the activities of sequentially interacting serum proteins (some serine proteases), their receptors, and related regulatory proteins activated by cell-surface bound antibody, immune complexes, or a microbial membrane carbohydrate and involved in complex cascades (classical or properdin pathway) that generate Membrane Attack Complex, which creates target cell wall pores and lysis. The complement system also plays a role in antibody-dependent cytolysis, anaphylaxis, phagocytosis, opsonization, chemotaxis, and hemolysis.