Conserved Helix-Loop-Helix Ubiquitous Kinase

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Signaling Protein -> Conserved Helix-Loop-Helix Ubiquitous Kinase

Conserved Helix-Loop-Helix Ubiquitous Kinase Definition

Widely expressed by human CHUK Gene (Ser/Thr IKBK Family), 745-aa 85-kDa Conserved Helix-Loop-Helix Ubiquitous Kinase is an autophosphorylated cytoplasmic protein found in active heterodimer with IKK-beta bound to MAP3K14/NIK, MEKK1, IKAP, IKB-alpha-p65-p50 complex, and in complex with NCOA2, NCOA3, IKKB, IKBKG, and CREBBP. CHUK may interact with TRAF2, IKK-gamma/NEMO, and TRPC4AP. Inactivated by PP2A and activated by MAP3K14/NIK, AKT, and MEKK1, CHUK (or IKBKB) serine phosphorylates NFKB inhibitors (I-Kappa-Bs, NFKBIA or NFKBIB) leading to dissociation from cytoplasmically-trapped NFKB and ubiquitinated inhibitor degradation. Activated NFKB translocates to the nucleus, binds at kappa-B DNA binding motifs, and regulates transcription of target genes. CHUK also phosphorylates NCOA3. (NCI)

Conserved Helix-Loop-Helix Ubiquitous Kinase Synonyms

Conserved Helix-Loop-Helix Ubiquitous Kinase, CHUK, I Kappa-B Kinase Alpha, I-Kappa-B Kinase 1, IKBKA, IKK-Alpha, IKK1, IKKA, IKappaB Kinase, Inhibitor of Nuclear Factor Kappa-B Kinase Alpha Subunit, NFKBIKA, Nuclear Factor NFKappaB Inhibitor Kinase Alpha

Terms in Conserved Helix-Loop-Helix Ubiquitous Kinase category

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