Copper-Zinc Superoxide Dismutase
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Copper-Zinc Superoxide Dismutase Definition
Human superoxide dismutase [Cu-Zn] protein (153 aa, approximately 16 kD) is encoded by the SOD1 gene. This soluble, cytosolic protein acts as a homodimer that catalyzes the disproportionation of two superoxide radicals to yield molecular oxygen and hydrogen peroxide. Certain point mutations in the SOD1 gene produce misfolding of the protein product, resulting in reduced catalytic activity relative to the wild-type protein. This dysfunction has been shown to cause the development of amyotrophic lateral sclerosis.
Copper-Zinc Superoxide Dismutase Synonyms
Superoxide Dismutase [Cu-Zn], EC 1.15.1.1, SOD1 Protein
Terms in Copper-Zinc Superoxide Dismutase category
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