Core-Binding Factor Beta Subunit
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Core-Binding Factor Beta Subunit Definition
Part of the heterodimeric transcription factor Core-Binding Factor. CBF beta does not bind to DNA directly, but increases the affinity and stabilizes the binding of the CBF alpha (transcription factor AML1) for the CBF enhancer/promoter DNA site in TCR genes. CBF appears to regulate hematopoietic differentiation. Disruption of CBFB is associated with some leukemias. (from SWISS-PROT Q13951, OMIM 121360, and NCI)
Core-Binding Factor Beta Subunit Synonyms
Core-Binding Factor, Beta Subunit, CBF-Beta, CBFB, Core-Binding Factor Beta, Core-Binding Factor Beta Subunit, PEA2-Beta, PEBP2-Beta, PEBP2B, Polyomavirus Enhancer Binding Protein 2 Beta Subunit, SL3-3 Enhancer Factor 1 Beta Subunit, SL3/AKV Core-Binding Factor Beta Subunit
Terms in Core-Binding Factor Beta Subunit category
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