Cyclin-A2

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Cell Cycle Protein -> Cyclin -> Cyclin-A2

Cyclin-A2 Definition

Expressed at S-phase by human CCNA2 Gene (Cyclin A Subfamily) in all tissues tested (highest in testis), nuclear 432-amino acid 48.5-kD Cyclin A2 accumulates during G2, is abruptly destroyed at mitosis, controls the cell cycle, and promotes both G1/S and G2/M transitions. Inhibition of cyclin A synthesis or activity inhibits DNA synthesis. Highly conserved cyclins (proliferating cell nuclear antigens) regulate CDK kinases. Cyclin A interacts with CDK2 protein kinase and Ser/Thr kinase p34CDC2 (during G2/M) to form a holoenzyme complex; cyclin imparts substrate specificity to the complex. (from LocusLink, Swiss-Prot, OMIM, and NCI)

Cyclin-A2 Synonyms

Cyclin A2, CCNA2, Cyclin A

Terms in Cyclin-A2 category

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