Cyclin-B1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Cell Cycle Protein -> Cyclin -> Cyclin-B1

Cyclin-B1 Definition

Cyclin B1 is essential for control of the G2/M transition and the gene is expressed predominantly in the G2/M phase of cell division. Complexed with p34(cdc2), cyclin B1 forms mitosis-promoting factor (MPF), a serine/threonine kinase holoenzyme complex. Cyclin B1 imparts substrate specificity to MPF. Phosphorylation of cyclin B1 regulates nuclear translocation of MPF during prophase, essential for the induction and coordination of M-phase events. During cell cycle progression, a change in PLK1 kinase activity appears to phosphorylate cyclin B1 and stimulate nuclear entry of cyclin B1. (from SWISS-PROT P14635, OMIM 123836, and NCI)

Cyclin-B1 Synonyms

Cyclin B1, CCNB, CCNB1, CGB1, Cyclin B, G2/Mitotic-Specific Cyclin B1

Cyclin-B1

Cyclin-B1 Definition

Cyclin-B1 Synonyms

Terms in Cyclin-B1 category