Cancer Terms

Cyclin-D1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Cell Cycle Protein -> Cyclin -> Cyclin-D1

Cyclin-D1 Definition

Essential for control of the G1/S transition, cyclin D1 interacts with CDK4 and CDK6 to form a serine/threonine kinase holoenzyme and imparts substrate specificity to the complex. RB regulates cyclin D1 gene expression. Cyclin D1 expression may identify Barrett's esophagus patients at high risk for esophageal carcinoma; risk of progression to adenocarcinoma exhibits an odds ratio of 6.85. The BCL1 and PRAD1 oncogenes involve cyclin D1 gene translocations. (from J Natl Cancer Inst 2000. 92:1282 & 1316, SWISS-PROT P24385, OMIM 168461, and NCI)

Cyclin-D1 Synonyms

Cyclin D1, BCL1, CCND1, Cyclin D, D11S287E, G1/S-Specific Cyclin D1, PRAD1, U21B31

Terms in Cyclin-D1 category



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