Cyclin-D2

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Cell Cycle Protein -> Cyclin -> Cyclin-D2

Cyclin-D2 Definition

Human G1/S-specific cyclin D2 protein (289 aa, 33 kD) is encoded by the human cyclin D2 (CCND2) gene. This protein is essential for control of the G1/S phase of the cell cycle. Cyclin D2 protein binds to the protein kinases CDK4 and CDK6 (which are also required for the G1/S transition) to form a serine/threonine kinase haloenzyme complex. Cyclin D2 protein both regulates these protein kinases and confers substrate specificity to this complex. It also interacts with the Rb tumor suppressor protein and plays a role in the phosphorylation of this protein. Cyclin D2 protein plays a role in the proliferation of gonadal cells and is associated with malignant transformation of these cells. High levels of this protein have been detected in both ovarian and testicular tumors.

Cyclin-D2 Synonyms

Cyclin-D2, CCND2, G1/S-Specific Cyclin D2

Cyclin-D2

Cyclin-D2 Definition

Cyclin-D2 Synonyms

Terms in Cyclin-D2 category