Cyclin-Dependent Kinase Inhibitor-1B
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Cyclin-Dependent Kinase Inhibitor-1B Definition
Involved in G1 arrest, nuclear CDKN1B inhibits bound cyclin/CDK complexes and negatively regulates cell cycle progression. CDKN1B, a CASP-3 apoptotic target, is phosphorylated by CCNE1/CDK2, ubiquitinated by SKP2, and degraded. CDKN1B expression is regulated by PI3K/PKB and RAS/RAL regulated AFX-like forkhead proteins. Immunohistochemical detection of p27Kip1 may help to identify patients with gastric carcinomas, without lymph node involvement, who are at high risk of death. Low CDKN1B expression is strongly associated with a with poor prognosis. (from Int J Oncol 2001. 18:151, Cancer 2000. 89:2247, SWISS-PROT P46527, OMIM 600778, and NCI)
Cyclin-Dependent Kinase Inhibitor-1B Synonyms
Cyclin-Dependent Kinase Inhibitor 1B, CDKN1B, Cyclin-Dependent Kinase Inhibitor p27, p27-Kip1, p27Kip1
Terms in Cyclin-Dependent Kinase Inhibitor-1B category
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