Cancer Terms

Cyclin-Dependent Kinase-2

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Cell Cycle Protein -> Cyclin-Dependent Kinase -> Cyclin-Dependent Kinase-2

Cyclin-Dependent Kinase-2 Definition

Cyclin-Dependent Kinase 2, encoded by the CDK2 gene, belongs to the CDKX subfamily of the Ser/Thr protein kinase family. This protein kinase is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. It is involved in promoting DNA synthesis and cell cycle progression. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene exist. Its N-terminal domain interacts with cyclins and C-terminal domain interacts with CSK1. (From LocusLink, OMIM and NCI)

Cyclin-Dependent Kinase-2 Synonyms

Cyclin-Dependent Kinase 2, CDC2-Related Protein Kinase, CDK2, Cell Division Kinase 2, Cell Division Protein Kinase 2, EC 2.7.1.-, p33 Protein Kinase, p33(CDK2)

Terms in Cyclin-Dependent Kinase-2 category



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