Cyclin-Dependent Kinase-3

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Cell Cycle Protein -> Cyclin-Dependent Kinase -> Cyclin-Dependent Kinase-3

Cyclin-Dependent Kinase-3 Definition

Cyclin-Dependent Kinase 3, encoded by the CDK3 gene, belongs to the SER/THR family of protein kinases. CDK3 can phosphorylate histone H1. CDK3 is involved in the control of the cell cycle. CDK3 participates in the G1-S transition at least primarily by binding to E2F-1, E2F-2, or E2F-3 through DP-1 and by enhancing their transcriptional activities. CDK3 also interacts with cyclin E and cyclin A and Ik3-1/Cables is a novel substrate for CDK3-mediated phosphorylation by CDK3/cyclin E and CDK3/cyclin A. (From LocusLink, PubMed and NCI)

Cyclin-Dependent Kinase-3 Synonyms

Cyclin-Dependent Kinase 3, CDK3, Cell Division Protein Kinase 3, Cyclin-Dependent Protein Kinase 3, EC 2.7.1.-

Terms in Cyclin-Dependent Kinase-3 category

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