Cyclin-Dependent Kinase-4
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Cyclin-Dependent Kinase-4 Definition
A serine/threonine protein kinase involved in cell cycle control, Cdk4 may complex with D-type G1 Cyclins and belongs to the CDC2/CDKX subfamily. CDK4/CDK6 phosphorylates Rb in early G1, displacing histone deacetylase and blocking transcriptional repression. CDK4 is inhibited by p16 (Cyclin-Dependent Kinase Inhibitor-2). (NCI)
Cyclin-Dependent Kinase-4 Synonyms
Cyclin-Dependent Kinase 4, CDK4, CDK4 Protein, Cell Division Protein Kinase 4, Cyclin Dependent Kinase 4
Terms in Cyclin-Dependent Kinase-4 category
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